The Biochemistry department was started in 1993.

The history of the Botany department of this college dates back to 1912.

The Department of Biotechnology was started in 2002.

The Department of Business Administration (BBA) emerged in the year 1999.

The Undergraduate degree course in Commerce Computer Application (B.Com.CA) was started in the year 2008.

The Department of Chemistry was founded in 1906 by Rev. Fr. Augustin Hass SJ initiating the Undergraduate course in Chemistry.

The Department of Commerce was started in the year 1948. for offering the three-year B.Com degree.

The Department of Counselling Psychology was started in the academic year 2020-2021.

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The Department of Computer Science was started in the year 1983.

The Department of Information Technology was formally started in the year 2007.

The Department of Data Science was founded in the year 2020.

The Department of Economics was started as an under graduate department in 1844.

The Department of Electronics, St. Joseph's College was established in the year 1993.

The Department of English enjoys the special status of being the only department that has contact with every student at the undergraduate level.

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The Department of French had its inception in the college from the day it was started at Nagapattinam in 1844.

The Hindi Department has been functioning in this college for more than 5 decades.

The Department of Human Resource Management (originally Society, Culture and Civilization) was started in the year 1983.

The Department of History is as old as the College itself.

The Department of Mathematics was started as an under graduate department in 1844 at Nagapattinam.

The department of Physics was started with BA Physics programme in 1881 and was renamed to BSc Physics (Honours) in 1906.

The Department of Sanskrit was started in St. Joseph`s College in 1907 with Sri. T.V.Srinivasachariar as the first teacher.

The Department of B.Voc (Software Development and System Administration) was established in the year of 2014.

The Statistics Department was started in 1978.

The Department of Tamil was established in 1858.

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